WEHI-345 - CAS# 1354825-58-3 205 is an activator of the

is an activator of the Wnt pathway by acting in a Wnt ligand–dependent manner

[Epub ahead of print] PubMed PMID: 26079256

KU-55933 completely abrogates rapamycin-induced feedback activation of Akt

Crowther MA

InChiKey: PBCZSGKMGDDXIJ-NXNPIKFHSA-N

WEHI-345 - CAS# 1354825-58-3 205 is an activator of theWEHI 345, CAS No. 1354825 58 3, is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production. WEHI 345 delays RIPK2 ubiquitylation and NF B activation downstream of NOD engagement. Despite only delaying NF B activation on NOD stimulation, WEHI 345 prevents cytokine production in vitro and in vivo and ameliorates experimental autoimmune encephalomyelitis in mice. Product information CAS