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According to the National Institutes of Health, only about 1 to 2 percent of an oral dose actually makes it into your bloodstream

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Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease

Oral semaglutide bioavailability is significantly lower, estimated at 0.4 to 1% for standard oral formulations