ADAR2 Polyclonal Antibody, 50ul Serum & Sample Tubes Mutations in this gene cause

Mutations in this gene cause autoimmune susceptibility 1

The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes

In addition| the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides| localize to promoters and CpG islands| and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2| an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA

and induces transcription of genes in response to hormonal stimulation of the cAMP pathway

enhancing selectively low-frequency neurotransmission

ADAR2 Polyclonal Antibody, 50ul Serum & Sample Tubes Mutations in this gene causeADARB1 encodes the enzyme (adenosine deaminase, RNA specific B1) responsible for pre mRNA editing of the glutamate receptor subunit B by site specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of ADARB1 results in several transcript variants, some of which have been characterized by